Bo Peng

Bo Peng

Professor, assistant director

Institute for Translational Brain Research

Fudan University, China

About the Speaker:

Dr. Bo Peng is a professor and assistant director at Institute for Translational Brain Research, Fudan University. He obtained his bachelor's degree in biotechnology in 2008 at Huazhong University of Science and Technology. He then studied neurophysiology at the Institute of Neuroscience at the Chinese Academy of Sciences from 2008 to 2011. After that, he investigated retinal degenerative disorders at The University of Hong Kong and obtained his Ph.D. degree in neuroscience in 2015. After that, Dr. Bo Peng joined Shenzhen Institutes of Advanced Technology at the Chinese Academy of Sciences as an associate professor and established his lab. In 2019, Dr. Bo Peng moved to Fudan University.

Dr. Bo Peng's laboratory is mainly focusing on understanding how microglia turnover in physiological and pathological conditions. In addition, his lab is developing therapeutic approaches for treating CNS disorders. Dr. Bo Peng published a series of last-author papers, including Nature Neuroscience (2018), Nature Aging (2023), Neuron (2021), Cell Reports (2020), Nature Communications (2022), and eLife (2023).

Selected Recent Publications:

1. Li X, Li Y, Jin Y, Zhang Y, Wu J, Xu Z, Huang Y, Cai L, Gao S, Liu T, Zeng F, Wang Y, Wang W, Yuan TF, Tian H, Shu Y, Guo F, Lu W, Mao Y, Mei X, Rao Y, Peng B (2023) Transcriptional and epigenetic decoding of the microglial aging process. Nat Aging 3:1288-1311.

2. He Y, Liu T, He Q, Ke W, Li X, Du J, Deng S, Shu Z, Wu J, Yang B, Wang Y, Mao Y, Rao Y, Shu Y, Peng B (2023) Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner. eLife 12:RP92252.

3. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brone B, Brown GC, Butovsky O et al. (2022) Microglia states and nomenclature: A field at its crossroads. Neuron 110:3458-3483.

4. Zhou T, Li Y, Li X, Zeng F, Rao Y, He Y, Wang Y, Liu M, Li D, Xu Z, Zhou X, Du S, Niu F, Peng J, Mei X, Ji SJ, Shu Y, Lu W, Guo F, Wu T, Yuan TF, Mao Y, Peng B (2022) Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun 13:6233.

5. Rao Y, Du S, Yang B, Wang Y, Li Y, Li R, Zhou T, Du X, He Y, Wang Y, Zhou X, Yuan TF, Mao Y, Peng B (2021) NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming. Neuron 109: 4094-4108.e5.