Ralf Jauch

Ralf Jauch

Associate Professor

School of Biomedical Sciences

Li Ka Shing Faculty of Medicine

The University of Hong Kong, Hong Kong, China

About the Speaker:

Professional Appointments in Research:

Since 2020: Principal Investigator. Center for Translational Stem Cell Biology.

2016-2021: Deputy Director. Max Planck - GIBH Join Center for Regenerative Biomedicine.

2016-2018: Adjunct Professor, Guangzhou Medical University, China

2013-2018: Principal Investigator and Professor. Guangzhou Institutes of Biomedicine and Health. Chinese Academy of Sciences. Guangzhou, China.

2008-2013: Research Scientist. Genome Institute of Singapore (A*STAR). Singapore.

Research Interests:

Cellular reprogramming

Directed molecular evolution in mammalian cells

Synthetic transcription factors

Structure-function relationships in gene regulation

Deep sequencing and data science

Selected Recent Publications:

1. Weng MX, Hu HQ, Graus MS, Tan DS, Gao Y, Ren SM, Ho DHH, Langer J, Holzner M, Huang YH, Ling GS, Lai CSW, Francois M, Jauch R (2023) An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming. Sci Adv 9:eadh2501.

2. Hu HQ, Ho DHH, Tan DS, MacCarthy CM, Yu CH, Weng MX, Scholer HR, Jauch R (2023) Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17. Nucleic Acids Res 51:8934-8956.

3. Fu XL, Zhuang Q, Babarinde IA, Shi LY, Ma G, Hu HQ, Li YH, Chen J, Xiao Z, Deng BP, Sun L, Jauch R, Hutchins AP (2023) Restricting epigenetic activity promotes the reprogramming of transformed cells to pluripotency in a line-specific manner. Cell Death Discov 9:245.

4. Chen YH, Lu JS, Xu YW, Huang YP, Wang DZ, Liang PL, Ren SF, Hu XS, Qin YW, Ke W, Jauch R, Hutchins AP, Wang M, Tang FC, Zhao XY (2023) The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting. Protein Cell 14:477-496.

5. Tan DS, Cheung SL, Gao Y, Weinbuch M, Hu HQ, Shi LY, Ti SC, Hutchins AP, Cojocaru V, Jauch R (2023) The homeodomain of Oct4 is a dimeric binder of methylated CpG elements. Nucleic Acids Res 51:1120-1138.