Xushen Xiong

Xushen Xiong

Assistant Professor

Zhejiang University Medical Center, China

About the Speaker:

Dr. Xushen Xiong is a Principal Investigator at Zhejiang University Medical Center. He received his PhD degree in Integrative Biology from Peking University (advisor: Professor Chengqi Yi) in 2019, with a focus on RNA modifications and bioinformatics. He then did his postdoc research with Professor Manolis Kellis (Head of MIT Computation Biology) at MIT Computer Science & Artificial Intelligence Laboratory. Dr. Xiong has been focused on using a combination of bioinformatic and machine-learning approaches to decipher the molecular basis of human brain diseases, specifically Alzheimer’s disease. As the first/co-first author, Dr. Xiong has published a series of papers in top journals, including Cell, Nature Genetics, Molecular Cell, Nature Chemical Biology, and more. These publications have been well recognized by the community and have been cited for over 2100 times according to Google Scholar.

Selected Recent Publications:

1. Xiong XS, James BT, Boix CA, Park Y, Galani K, Victor MB, Sun N, Hou L, Ho LL, Mantero J, Scannail AN, Dileep V, Dong WX, Mathys H, Bennett DA, Tsai LH, Kellis M (2023) Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion. Cell 186:4422-4437.

2. Sun N, Victor MB, Park YP, Xiong XS, Scannail AN, Leary N, Prosper S, Viswanathan S, Luna X, Boix CA, James BT, Tanigawa Y, Galani K, Mathys H, Jiang XQ, Ng AP, Bennett DA, Tsai LH, Kellis M (2023) Human microglial state dynamics in Alzheimer's disease progression. Cell 186:4386-4403.e29.

3. Hou L, Xiong XS, Park Y, Boix C, James B, Sun N, He L, Patel A, Zhang ZZ, Molinie B, Van Wittenberghe N, Steelman S, Nusbaum C, Aguet F, Ardlie KG, Kellis M (2023) Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease. Nat Genet 55:1665-1676.

4. Xiong XS, Hou L, Park Y, Molinie B, GTEx Consortium, Gregory RI, Kellis M (2021) Genetic drivers of m6A methylation in human brain, lung, heart and muscle. Nat Genet 53:1156-1165.

5. Wang YY, Wang J, Li XY, Xiong XS, Wang JY, Zhou ZH, Zhu XX, Dominissini D, Gu Y, He L, Tian Y, Yi CQ, Fan ZS (2021) N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun 12:6314.