Completed: June 13 Molecular Therapies for Genetic Peripheral Neurodegeneration
Title: Molecular Therapies for Genetic Peripheral Neurodegeneration
Date and Time:
The 13th of June, Tuesday
20:30-21:50 (Beijing) | 13:30-14:50 (London) | 14:30-15:50 (CET) | 8:30 am-9:50 am (EST)
Yi “Joey” Zhou
University of Pennsylvania, Philadelphia, PA, USA
About the Session Chair: Dr. Yi “Joey” Zhou received dual Bachelor’s Degrees of Sciences in 2012 from East China Normal University in Shanghai, China and Colorado State University in the United States. He received his Ph.D. in Neuroscience from Johns Hopkins University in 2018. He then worked as a Postdoctoral Researcher and a Research Associate at the University of Pennsylvania from 2018 to 2023. Joey joined the Institute of Neurosciences at the Chinese Academy of Sciences as a Principal Investigator in August 2023, where he leads the Laboratory of Neurogenesis and Brain Disorders to investigate mechanisms regulating neurogenesis, adult neural stem cells and newborn neurons, and brain disorders.
Our research group uses hippocampal neurogenesis as a biological system and employs cutting-edge technology platforms such as single-cell multi-omic sequencing, transgenic animal models, human brain cell and slice culture models, and time-lapse confocal imaging, in combination with computational biology tools such as machine learning and deep learning to analyze and mine large datasets to deeply analyze the regulatory mechanisms of brain development and disease. Our previous work based on transgenic mouse models revealed multiple levels of regulatory mechanisms during hippocampal adult neurogenesis, including the regulation and maintenance of adult neural stem cell quiescence (Cell Stem Cell 2018), differentiation and fate choice (Nature Neuroscience 2015), and migration of newborn immature neurons (PNAS 2015). Our recent research focuses on exploring the multi-modal characteristics and regulation of this process in the human brain: we have mapped single-cell molecular landscapes of various important cell types, including human hippocampal immature neurons, across the lifespan and in Alzheimer's disease, and used brain slice culture models to demonstrate the capacity for the adult hippocampus to generate new neurons (Nature 2022; Cell Stem Cell 2022).
The goal of our research group is to reveal the molecular and cellular mechanisms of hippocampal neurogenesis and the changes in this process in different species, ages, and diseases. We will comprehensively use and expand our technology platforms to characterize and functionally analyze key cell types such as hippocampal neural stem cells and newly born immature neurons at multiple levels. We hope that through these studies we can reveal the biological basis of neural development and regeneration and provide new strategies for using stem cells and newly born neurons to treat brain injuries and diseases.
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, China
About the Panelist: Liao, Song-Jie, Chief Physician, a committee member of Chinese Medical Association and Chinese Medical Doctor Association in clinical neurophysiology. Her main research area is related to peripheral neuropathy and clinical neurophysiology. She has held several grants from National Natural Scientific Foundation and also other grants, and published international peer reviewed articles.
Wuhan National Laboratory for Optoelectronics in Huazhong University of Science and Technology, China
About the Panelist: Dr. Haiming Luo, Professor of Wuhan National Laboratory for Optoelectronics in Huazhong University of Science and Technology. Prof Luo received his PhD degree in Biomedical Engineering from Huazhong University of Science and Technology, then he did postdoc training from Prof. Weibo Cai's lab in the University of Wisconsin-Madison, Prof. Annie Chan's lab in the Massachusetts General Hospital of Harvard Medical School from 2013 to 2018. During this period, Dr. Luo also received neuroscience training as a research associate in McGovern Institute for Brain Research Department of Brain and Cognitive Sciences, MIT.
Institute for Brain Sciences Research, School of Life Sciences, Henan University, China
About the Panelist: Dr. Jianshe Wei is the Yellow River Scholar professor and the supervisor for Ph.D. candidates on neurobiology in Henan University. He graduated from Shanghai Medical College of Fudan University on Ph.D. degree in medical neurobiology. He is currently the director of the Institute of Neurobiology and head of the Laboratory of Brain Function and Molecular Neurodegeneration at Henan University.
His research interests include the molecular, cellular, and microcircuit mechanisms of neurodegeneration in Parkinson's disease, deciphering the effects of brain cell energy metabolism and oxidative stress on neurodegeneration and subcellular organelle function, neuroplasticity and dementia, exercise and brain stress adaptation, investigating the effects of exercise on non-motor symptoms of PD, especially depression on neurocircuit level, and exploring the cellular and molecular mechanisms of exercise-induced brain neural regeneration. He also investigates the cellular and molecular mechanisms of brain neurodegeneration in abnormal disorders, and provides the experimental evidence and therapeutic directions for repairing the brain neurological damage caused by aging and diseases. Dr. Wei has published more than 40 papers in Neuron, Nat Commun, Cell & Bioscience, AJP, JBC, J Neuroinflammation, and other related academic journals. He has received more grants from the National Natural Science Foundation of China (NSFC), the Natural Science Foundation of Henan Province, and the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) Foundation (B). He was awarded the third prize for Science and Technology Progress in Henan Province. He has co-edited 2 English monographs and gained 7 patents. He is a member of the Neural Regeneration and Repair Committee of the Chinese Society of Research Hospitals, a council member of the Henan Biophysical Society, a deputy director of the Henan Infection and Immunity Committee and the other 8 academic part-time positions. He is also a reviewer for NRR, the Ministry of Education Degree Centre, and NSFC et al.
Attending Physician, Lecturer
Xijing Hospital, Fourth Military Medical University, China
About the Panelist: Xiuquan Wu, Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Attending physician, Lecturer. Bachelor, master, doctor and postdoctoral candidate, graduated from the Fourth Military Medical University. He studied under Professor Fei Zhou, a famous neurosurgery and traumatologist in China, and his teacher was Professor Yi Shengyu, a pioneer in neurosurgery in China. The research mainly focuses on the molecular pathological mechanism of brain injury and brain injury prevention strategies. Up to now, more than 40 academic papers have been published, 13 SCI papers have been published by the lead author and co lead author, of which the highest impact factor of a single article is 11.061, and 7 patents have been obtained. He have undertaken two excellent degree thesis and doctoral research funding projects, and participated in more than 10 national and provincial level projects, including the National Natural Science Foundation Key Project and 173 Project. Selected for the university's "New Flight Program" talent program, currently serving as a reviewer for SCI journals such as Neural Regeneration Research and Frontiers in Cellular Neuroscience.
Main research directions:
1. Carry out a series of basic research on brain injury and make significant progress in the molecular pathological mechanisms of neuronal injury. Focusing on the key molecular mechanisms of neuronal damage repair, research has found that molecules such as Homer, Parkin, and Pink1 can exert neuroprotective effects, and in-depth research has been conducted on their regulatory signaling pathways. Relevant research has been published in high-level journals such as Journal of Neuroinflammation、Cellular and Molecular Life Sciences.
2. Conducting a series of clinical studies on traumatic brain injury has made significant breakthroughs in exacerbating the risk factors of secondary brain injury. Focusing on the key role of risk factors that exacerbate secondary brain injury in the timely prevention and treatment of traumatic brain injury, retrospective and prospective clinical studies were conducted. A database of over 1100 clinical patients was established, and a secondary brain injury risk factor detection system was developed. The study found that multimodal monitoring of secondary brain injury risk factors can benefit the injured. The relevant research was published in the Chinese Journal of Neurotrauma Surgery Journal of Trauma Surgery and other high-level journals, and participated in the writing of guidelines for timely treatment of traumatic brain injury.
3. Conducting a series of applied research on craniocerebral trauma and achieving significant progress in skull regeneration and repair. Focusing on the role of biological 3D printing technology in skull defects caused by war trauma, conducting applied research, and successfully obtaining a new type of skull repair material based on autologous bone powder loaded stem cells. Relevant research has been published in high-level journals such as Biofabrication.