Frank Bradke

Frank Bradke

教授，组长

德国神经退行性疾病中心 (DZNE)

波恩，德国

关于演讲人：

研究重点领域

Bradke实验室的研究重点是神经细胞在发育过程中如何生长，以及如何重新激活这些过程以诱导受伤脊髓的神经再生。

该实验室对细胞骨架特别感兴趣。

Bradke和他的同事认为，用低剂量的抗癌药操纵细胞骨架可导致神经再生并减少疤痕。

他的实验室还开发了一种新的成像技术，能够在整个组织内以显微镜的分辨率观察神经。

Selected Recent Publications:

Santos TE, Schaffran B, Broguière N, Meyn L, Zenobi-Wong M, Bradke F (2020) Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions. Cell Rep32:107907.

Dupraz S, Hilton BJ, Husch A, Santos TE, Coles CH, Stern S, Brakebusch C, Bradke F (2019) RhoA Controls Axon Extension Independent of Specification in the Developing Brain. Curr Biol 29:3874-3886.e9.

Tedeschi A, Dupraz S, Curcio M, Laskowski CJ, Schaffran B, Flynn KC, Santos TE, Stern S, Hilton BJ, Larson MJE, Gurniak CB, Witke W, Bradke F (2019) ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Neuron 103:1073-1085.e6.

Hilton BJ, Blanquie O, Tedeschi A, Bradke F (2019) High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nat Protoc 14:1235-1260.

Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F (2016) The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Neuron   92:419-434.

Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F (2015) Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science 348:347-52.