Gunnar HD Poplawski

Gunnar HD Poplawski

博士

杜克-新加坡国立大学医学院，新加坡

研究方向：识别神经退行性疾病的细胞类型特异性、脑源性生物标志物等

鉴别预测大脑损伤发生和严重程度的临床相关生物标志物对于确定患有慢性和急性损伤（如痴呆和神经创伤）个体的合理治疗至关重要。 我的研究方案旨在鉴别神经退行性疾病（如阿尔茨海默病-AD）的细胞类型特异性、脑源性生物标志物。 我们正在利用血液生物标志物的非侵入性鉴定，这些生物标志物有可能精确诊断患有 AD 和其他神经退行性疾病（包括不同形式的痴呆、神经创伤、脑肿瘤和衰老）的患者。

近年发表文章

1. Gunnar H D Poplawski, Riki Kawaguchi, Erna Van Niekerk, Paul Lu, Neil Mehta, Philip Canete, Richard Lie, Ioannis Dragatsis, Jessica M Meves, Binhai Zheng, Giovanni Coppola, Mark H Tuszynski. Injured adult neurons regress to an embryonic transcriptional growth state. Nature. 2020 May;581(7806):77-82.

2. Hannah A Grunwald, Valentino M Gantz, Gunnar Poplawski, Xiang-Ru S Xu, Ethan Bier, Kimberly L Cooper. Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2019 Feb;566(7742):105-109.

3. Gunnar Poplawski, Tetsuhiro Ishikawa, Coralie Brifault, Corinne Lee-Kubli, Robert Regestam, Kenneth W Henry, Yasuhiro Shiga, HyoJun Kwon, Seiji Ohtori, Steven L Gonias, Wendy M Campana. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia. 2018 Aug;66(8):1577-1590.

4. Akash Patel, Zhongzhi Li, Philip Canete, Hans Strobl, Jennifer Dulin, Ken Kadoya, Dan Gibbs, Gunnar H D Poplawski. AxonTracer: a novel ImageJ plugin for automated quantification of axon regeneration in spinal cord tissue. BMC Neurosci. 2018 Mar 9;19(1):8.

5. Jennifer N Dulin, Andrew F Adler, Hiromi Kumamaru, Gunnar H D Poplawski, Corinne Lee-Kubli, Hans Strobl, Daniel Gibbs, Ken Kadoya, James W Fawcett, Paul Lu, Mark H Tuszynski. Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. Nat Commun. 2018 Jan 8;9(1):84.