Sing Yian Chew

Sing Yian Chew

副教授

南洋理工大学，新加坡

研究方向：用于再生医学的仿生材料

我们实验室设计了生物功能微纳米结构支架，以了解和指导细胞行为。 使用涉及基质形貌/顺应性和生化线索的组合方法介导组织再生和宿主 - 植入物整合。

我们的工作范围涉及基础科学、支架、药物或基因递送技术开发以及转化研究。 目前，我们专注于研究支架介导的基因沉默方法，以了解和指导神经组织再生、干细胞分化和宿主 - 植入物整合。

我们的主要目标是提供改进的平台，以更好地了解和控制再生医学的细胞命运。

近年发表文章

1. Na Zhang, Junquan Lin, Vincent Po Hen Lin, Ulla Milbreta, Jiah Shin Chin, Elaine Guo Yan Chew, Michelle Mulan Lian, Jia Nee Foo, Kunyu Zhang, Wutian Wu, Sing Yian Chew. A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury. Advanced Science. 29 May 2021.

2. Wai Hon Chooi, Quanbin Dong, Jeremy Zhi Yan Low, Clement Yuen, Jiah Shin Chin, Junquan Lin, William Ong, Quan Liu and Sing Yian Chew. Cell Membrane-Coated Electrospun Fibers Enhance Keratinocyte Growth through Cell-Type Specific Interactions. ACS Applied Bio Materials. April 21 2021, 4 (5), pp. 4079-4083.

3. Vincent Kwok, Lim Lam, Johnny Yu Hin Wong, Sing Yian Chew, Barbara Pui Chan. Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues. Biomaterials. 24 April 2021. 274, pp. 120829.

4. Nicolas Marinval and Sing Yian Chew. Mechanotransduction assays for neural regeneration strategies: A focus on glial cells. APL Bioengineering. 30 April 2021. 5, pp. 021505.

5. Po Hen Lin, Quanbin Dong and Sing Yian Chew. Injectable hydrogels in stroke and spinal cord injury treatment: a review on hydrogel materials, cell–matrix interactions and glial involvement. Materials Advances, 2, pp. 2561-2583.