08:30-09:45 Keynote Speech 1

Moderators:

James N. Sleigh (University College London, UK)

Jie Wang (Shanghai Jiao Tong University, China)

08:30-09:15 Viral vector-based interventions to enable axon regeneration after spinal cord injury: progress, caveats, and new approaches to track vector cargo expression in live animals

Oswald Steward (University of California, Irvine, USA)

09:15-09:45 Discussion

09:45-10:00 Coffee break

10:00-12:30 Session 01: Optic Nerve Regeneration and Microglia Research

Moderators:

Qingfen Yu (The Third Affiliated Hospital, Sun Yat-Sen University, China)

Qiyi Zhao (The Third Affiliated Hospital, Sun Yat-Sen University, China)

10:00-10:30 Regeneration of optic nerve in rats and monkeys

Kwok-fai So (The University of Hong Kong; Jinan University, China)

10:30-11:00 Effect of retinal damage on muller glia reprogramming in zebrafish

David R. Hyde (University of Notre Dame, USA)

11:00-11:30 Reprogramming Müller glia for neurogenesis and vision restoration in adult mouse retinas

Bo Chen (Icahn School of Medicine at Mount Sinai, USA)

11:30-12:00 Turnover & replacement: a philosophy of microglia

Bo Peng (Fudan University, China)

12:00-12:30 Discussion

12:30-13:30 Lunch break

13:30-14:35 Keynote Speech 2

Moderators:

Wutian Wu (Jinan University, China)

Libing Zhou (Jinan University, China)

Jiasong Guo (Southern Medical University, China)

13:30-14:15 Immune and metabolic control of sensorimotor function in physiology and after injury

Simone Di Giovanni (Imperial College London, UK)

14:15-14:35 Discussion

14:35-16:25 Session 02: Aging Core: Protein Aggregation and Proteostasis

Moderators:

Yanxia Rao (Fudan University, China)

Wang Liao (The Second Affiliated Hospital of Guangzhou Medical University, China)

Guojun Shi (The Third Affiliated Hospital, Sun Yat-Sen University, China)

14:35-15:05 A structure-based approach to tackle protein aggregation in Parkinson's disease

Salvador Ventura (Universitat Autònoma de Barcelona, Spain)

15:05-15:35 Stem cell models for aging-associated neurodegenerative diseases

Ralf Jauch (The University of Hong Kong, China)

15:35-16:05 Genetic and epigenetic dissection of human brain diseases using statistical genetics approaches

Xushen Xiong (Zhejiang University, China)

16:05-16:25 Discussion

16:25-16:35 Coffee break

16:35-18:25 Session 03: Rising Stars in Neural Regeneration

Moderators:

Xiaoming Hu (University of Pittsburgh, USA)

Yibo Qu (Jinan University, China)

16:35-17:05 Myelin – a favorable niche for Glioblastoma and Neuronal stem cells

Gunnar H.D. Poplawski (Cleveland Clinic, USA)

17:05-17:35 Restoring axonal transport as a therapeutic strategy in peripheral neurodegeneration

James N. Sleigh (University College London, UK)

17:35-18:05 Non-image-forming visual functions and brain function regulation

Lu Huang (Jinan University, China)

18:05-18:25 Discussion

18:30-20:30 Banquet & Open Ceremony

08:30-10:30 Session 04: Regenerative Medicine

Moderators:

Qifei Cong (Soochow University, China)

Letao Yang (Tongji University, China)

08:30-09:00 Why do umbilical cord blood mononuclear cells restore walking in patients with chronic complete spinal cord injury?

Wise Young (Rutgers, The State University of New Jersey, USA)

09:00-09:30 Protecting the nervous system across generations with the maternal diet

Roger Pocock (Monash University, Australia)

09:30-10:00 Adult axon guidance to reform a functional neuronal circuit in the visual system

Homaira Nawabi (Grenoble Institut Neurosciences, France)

10:00-10:30 Discussion

10:30-10:45 Coffee break

10:45-12:15 Session 05: Biomarker Research in Neurodegenerative Disorders

Moderators:

Linhua Jiang (Xinxiang Medical University, China)

Li Zhang (Jinan University, China)

10:45-11:15 CNS-originating extracellular vesicles allow highly sensitive biomarker detection in neurodegenerative diseases

Gal Bitan (University of California Los Angeles, USA)

11:15-11:45 The emerging role of blood biomarkers for the differential diagnosis of dementia

Alberto Benussi (University of Brescia, Italy)

11:45-12:15 Discussion

12:15-13:30 Lunch break

13:30-17:30 Young Scientists Forum 1 (English)

Moderators:

Jin Jin (The Third Affiliated Hospital, Sun Yat-Sen University, China)

Wang Liao (The Second Affiliated Hospital of Guangzhou Medical University, China)

Referees: Oswald Steward, Wise Young, Homaira Nawabi, Xushen Xiong

Dpp4 subset of adipose cells in the spinal epidural fat has neuroprotective function through release EVs

Yong Cao (Xiangya Hospital Central South University)

Spinal cord specific extracellular matrix enhances neuroepithelial expansion and ventral identity of spinal cord organoids

Yanjun Guan (Chinese PLA General Hospital)

Novel multilayer magnesium silicate nanosheets-enabled sustained hydrogen generation for targeted therapy of hemorrhagic stroke

Maotao He (Shandong Second Medical University)

The role of remyelination in ketamine’s antidepressant effect

Chaoli Huang (Jiangsu Province Hospital)

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes

Weijun Huang (The Third Affiliated Hospital of Sun Yat-sen University)

Endothelium-specific inhibition of Foxo1 phosphorylation mitigates Osteopontin-induced pathological vascular remodeling following spinal cord injury

Liyuan Jiang (Xiangya Hospital Central South University)

Injectable porous hydrogels with ADSCs-induced NSCs promote nerve regeneration by modulating immune microenvironment in a rat model of sacral nerve injury

Junyang Li (Chinese PLA General Hospital)

The challenge of methylprednisolone in the treatment of spinal cord injury

Yuanlong Li (Guangdong Provincial People's Hospital)

Extracellular mitochondria contribute to acute lung injury via disrupting macrophages after traumatic brain injury

Yafan Liu (Tianjin Medical University General Hospital)

Integrated hydrogel promotes precise projection of regenerating axons of spinal cord injury treatment

Junwu Ma (The Third Affiliated Hospital of Sun Yat-sen University)

Activity dependent myelin repair in spinal cord injury

Botao Tan (The Second Affiliated Hospital of Chongqing Medical University)

Investigation of Proprioception Evaluation Methods and Mechanisms Established on Agonist-Antagonist Myoneural Interface Technology

Chunxiao Tang (Shenzhen Institute of Advanced Technology of the Chinese Academy of Science)

Digestion of CSPGs in the motoneuronal pool remote to a thoracic spinal cord injury promotes neuronal plasticity and locomotor recovery

Yongzhi Xia (The First Affiliated Hospital of Chongqing Medical University)

A novel magnetic responsive miR-26a@SPIONs-OECs for spinal cord injury: triggering neural regeneration program and orienting axon guidance in inhibitory astrocytic environment

Yujie Yang (Xijing Hospital)

Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis

Senyu Yao (The Third Affiliated Hospital of Sun Yat-sen University)

BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury

Qing Zeng (ZhuJiang Hospital of Southern Medical University)

13:30-17:30 Young Scientists Forum 2 (English)

Moderators:

Liumin He (The Third Affiliated Hospital, Sun Yat-Sen University, China)

Chaojin Chen (The Third Affiliated Hospital, Sun Yat-Sen University, China)

Referees: Simone Di Giovanni, David R. Hyde, Bo Chen, Gunnar H.D. Poplawski

Exploration of in situ overexpression of transcription factor combination on retinal repair ability

Weike Deng (Jinan University)

The role and mechanism of ferroptosis-mediated neuronal cell death in the spinal cord in chronic inflammatory pain

Yifan Deng (The Third Affiliated Hospital of Sun Yat-sen University)

The role and targeted regulation therapy of lysosomal membrane permeabilization in spinal cord injury

Yibo Geng (The Second Affiliated Hospital of Wenzhou Medical University)

Exploring the cellular biological mechanisms of chitosan conduit loading sustained release exosomes in 3D culture of BMSCs for repair of peripheral nerve injury in rats

Haoran Jiang (Peking University People's Hospital)

A fully-implantable multisite optogenetic stimulation system and its long-term multimodal application in precise control of forelimb in mice

Su Jiang (Huashan Hospital of Fudan University)

A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves

Chaochao Li (Chinese PLA General Hospital)

NSC-derived Neural Tissueoid Rebuilded Neural Circuits in Spinal Cord Transected Completely

Ge Li (Guangdong Provincial People's Hospital-Southern Medical University)

AI-Powered the development of treatments for spinal cord injury

Xuhua Wang (Zhejiang University)

Macrophages reside in the muscle spindle to control sensorimotor function at a millisecond timescale

Yuyang Yan (Imperial College London)

Functional exosomes in central nervous system diseases therapy

Lingyan Yang (Guangzhou Laboratory)

Sequential oxygen supply system promotes peripheral nerve regeneration by enhancing Schwann cells survival and angiogenesis

Beibei Yu (Xijing Hospital)

Development of an excitatory neural network-skeletal muscle assembloids that responds to motor regulation

Haiyang Yu (Guangdong Provincial People's Hospital)

The role and mechanism of FDFT1 in regulating the biological function of macrophages involving in peripheral nerve injury

Jiaqi Zhang (Southern Medical University)

Cell adaptable hydrogel regulates stem cell behaviors and promotes spinal cord injury repair

Kunyu Zhang (South China University of Technology)

Raddeanin A protects BRB in the retina of Alzheimer’s disease

Xilai Zhang (Southwest Medical University)

13:30-17:30 Young Scientists Forum 3 (English)

Moderators:

Lu Huang (Jinan University, China)

Changyong Tang (The Third Affiliated Hospital, Sun Yat-Sen University, China)

Referees: Kwok-fai So, Roger Pocock, James N. Sleigh, Lu Huang

A clinical study about thrombolysis in patients with minor nondisabling acute stroke

Yiming Cai (The Fifth Affiliated Hospital of Sun Yat-Sen University)

Lactate-derived HDAC6 Lactylation as a new target for neuronal protection in cerebral ischemic reperfusion injury

Jun Cao (Shenzhen Maternity & Child Healthcare Hospital)

HF-rTMS improves swallowing function in rats with post stroke dysphagia by upregulating NTS excitability

Jiemei Chen (The Third Affiliated Hospital of Sun Yat-sen University)

Imaging transcriptomics of the brain for aging in schizophrenia

Longbiao Cui (Xijing 986 Hospital)

Swallowing sensorimotor network changes after stroke: cumulative evidence from current research

Meng Dai (The Third Affiliated Hospital of Sun Yat-sen University)

The role and mechanism of TSP1 in depression

Shuangqi Gao (The Third Affiliated Hospital of Sun Yat-sen University)

Thonningianin A extracted from Penthorum chinense Pursh ameliorates cerebral ischemia-reperfusion injury by suppressing cell pyroptosis

Guishan Hu (Southwest Medical University)

Siramesine attenuates early brain injury through TMEM97/NPC1 pathway after experiment subarachnoid hemorrhage in rats

Shuai Lan (The First Affiliated Hospital of Harbin Medical University)

Peri-vascular macrophage (PBM)-derived MANF promotes glymphatic clearance of Amyoid-β (Aβ) after ischemic stroke

Chunyi Li (The Third Affiliated Hospital of Sun Yat-sen University)

The effect of active components of Citri Reticulatae Semen on neuron function and motor ability of A53T- αSyn-Tg mice

Shuaibing Li (Southwest Medical University)

Medium-intensity statin with ezetimibe versus high-intensity statin in acute ischemic cerebrovascular disease (MESIA): A randomized clinical trial

Yanfang Peng (The Fifth Affiliated Hospital of Sun Yat-Sen University)

Developing an Animal Model of Coal Mine Gas Explosion and Understanding the Injury Mechanism

Linqiang Tian (The Third Affiliated Hospital of Xinxiang Medical University)

Evidence of local neurogenesis in ischemic cortex

Yazhou Wang (Air Force Medical University of PLA)

The phagocytosis of neurovascular unit in the central nervous system

Tian Zhou (Southern Medical University)

Mechanisms of RIPostC maintaining Th17/Treg cell homeostasis to ameliorate cognitive impairment after SAH in rats by regulating STAT3/STAT5 phosphorylation

Yajun Zhu (The First Affiliated Hospital of Chongqing Medical University)

Departure