Completed: Proteostasis in the Endoplasmic Reticulum: Age-Related Diseases

Topic: Proteostasis in the Endoplasmic Reticulum: Age-Related Diseases

Date and Time:

The 30th of November, THURSDAY

20:00-21:00 (Beijing) | 9:00 am - 10:00 am (Chile)

PROGRAM

Invited Speaker:

Claudio Hetz

Professor

Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Chile; Buck Institute for Research on Aging, USA

Speech Title: Improving ER proteostasis delays brain aging and age-related diseases

About the speaker: Prof. Claudio Hetz joined the University of Chile during 2007 and is currently Full Professor at Faculty of Medicine, in addition to hold and adjunct Professor position at the Buck Institute for Research in Aging in California and a visiting professor position at Harvard. He is also currently the Director of the Biomedical Neuroscience Institute (BNI) and associate investigator of the Center for Geroscience, Brain health and Metabolism (GERO).

His research focused on understanding the molecular basis of protein folding stress, its relationship to pathological conditions affecting the nervous system including ALS, Parkinson′s disease, and Alzheimer’s disease and the development of prototypic strategies to prevent neuronal damage. One of his major areas of biotechnological development is gene therapy. This group is one of the most productive laboratories in Chile and Latin America and is currently supported by various national and international organizations. He has received important award including the KIA International Award, FEBS Anniversary Prize, TWAS-ROLAC and UNESCO Young Scientist Prize as outstanding young scientist in Latin America, the Santander Award, he was finalist in the Eppendorf and Science Award in Neurobiology, and was awarded with the Cell Biology Society and Bios-Chile prize as the best young scientist of Chile. Dr. Hetz H-factor is 55, publishing more than 200 papers with more than 18,000 citations.

Session Chair:

Jing-Wei Zhao

Professor and Principal Investigator

Institute of Neuroscience, Zhejiang University School of Medicine, China

About the Session Chair: Dr. Jing-Wei Zhao is a Professor and Principal Investigator in Institute of Neuroscience, Zhejiang University School of Medicine. He is also Associate Director of Cryo-Electron Microscopy Center Zhejiang University and Associate Director of Department of Human Anatomy, Histology and Embryology, Zhejiang University School of Medicine.

Dr. Zhao's Lab is now exploring how to encourage neural stem cells proliferate or become a specifc type of cells and how the brain ages? From Aug 2000 to Oct 2004 Dr. Zhao was an Associate Professor in Institute of Neurobiology, Fudan University. From Nov 2004 to 2013 Dr. Zhao did his postdoctoral research (Research Associate) on Neuroscience in Wellcome Trust-MRC Cambridge Stem Cell Institute and John van Geest Centre for Brain Repair, University of Cambridge. From May 2014 Dr. Zhao is a Professor and PI in Institue of Neuroscience, Zhejiang University School of Medicine. Dr. Zhao has published original papers in SCI journals including Cell Stem Cell, Nature Neuroscience, Nature Communications, Journal of Neuroscience, Glia, Critical Care Medicine and Cell Death Discovery. His papers have been cited over 3500 times so far (up to Mar 2023) . Dr. Zhao serves as Associate Editor for BMC Neuroscience and Review Editor for Frontiers in Cellular Neuroscience.

PANELIST 1:

Wang Liao

Assistant Research Professor

Department of Neurology at the Second Affiliated Hospital of Guangzhou Medical University, China

About the Panelist: Dr. Wang Liao, MD, PhD, serves as an Assistant Research Professor in the Department of Neurology at the Second Affiliated Hospital of Guangzhou Medical University. He is also dedicated to his role as the Chief Secretary of the National Core Advanced Cognitive Impairment Diagnosis and Treatment Center.

With a focus on the clinical understanding and underlying mechanisms of Alzheimer's disease, Dr. Liao has contributed to over 20 SCI-indexed publications and leads 13 research projects with a collaborative spirit.

His commitment to the field extends to his participation on editorial boards for respected journals such as Oxidative Medicine and Cellular Longevity and Translational Neuroscience. Additionally, Dr. Liao offers his academic service as a guest editor for Brain X.

PANELIST 2:

Quanhong Ma

Professor

Institute of Neuroscience, Soochow University, China

About the Panelist: Prof. Ma obtained her master degree in Dalian Medical University and Institute of Molecular Biology (IMCB), Singapore in 2005. She got her Ph.D. degree in University of Hamburg, Germany in 2008. Prof. Ma had worked on drug development as a senior scientist in GlaxoSmithKline, R&D (China) before joining to Soochow University. Prof. Ma joined to Soochow University as a full professor on Nov. 2010.

Prof. Ma’s research focuses on understanding the molecular and cellular mechanisms of Alzheimer’s disease and autism spectrum disorders. Her group tries to understand how dysregulated neural stem cells links to developmental disorders and the molecular regulation of autophagy. Prof. Ma’s research work has been published in Journal of Cell Biology, Cerebral Cortex, Neuropsychopharmacology, Aging Cell etc. Prof. Ma also actively participates scientific social activities. She is an Academic editor of Neuroscience Bulletin. Prof. Ma serves as Committee member of Chinese Society of Neuroscience, Endocrine Sub-professional Chinese Society of Neuroscience, Nerve Injury and Repair Branch of Chinese Society of Neurosciences, Society for Children's Cognition and Brain Dysfunction and Jiangsu Society of Neuroscience.

PANELIST 3:

Eugenia Morselli

Professor

Facultad de Medicina y Ciencia, Universidad San Sebastián, Chile

About the Panelist:

Prof. Eugenia Morselli moved to Chile in 2014, where she was assistant and then associated professor of the Department of Physiology of the Faculty of Biological Sciences of the Pontificia Universidad Católica de Chile. Since February 2022, she is Professor of the Faculty of Medicine and Sciences of the Universidad San Sebastián.

Their research objective is to understand the cellular mechanisms that control autophagy in the hypothalamus in response to high-fat diets, and in particular to the saturated fatty acids that are abundant in this type of diet and that accumulate in the brain when these are consumed. Role of the primary cilium in the sensing of nutrients. The primary cilium is a cellular antenna that in neurons functios as an extrasynaptic signaling center and a signaling platform. They show that this organelle can respond to fatty acids, regulating insulin signaling in neurons.

PANELIST 4:

Pei Shang

Research Scientist

Southern Medical University, China; Mayo Clinic, Rochester, USA

About the Panelist: Dr. Shang’s long-term research interests involve the pathogenesis and potential diagnostic biomarkers and pharmacological management underlying neurological disorders. While in college time, he has been selected as an outstanding undergraduate to visit the University of Manitoba for two academic semesters following Dr. Geoff G. Hicks (Director of Regenerative Medicine) to conduct ATAC-seq on a transgenic mouse model of fetal alcohol spectrum disorder.

Currently, he is serving as clinician and scientist in both Mayo Clinic and Southern Medical University in the area of neurological autoimmune diseases.

Working Experience:

2023/06-present   Research Scientist, Department of Neurology, Mayo Clinic, USA.

2022/09---present Neuroimmunology Research Fellow, Department of Neurology, Southern Medical University, China

2019/08---2021/05:   Research Fellow, Department of Neurology, Mayo Clinic, USA.

2017/09---2018/07:   Research Fellow, School of Medicine, University of Manitoba, Canada.