Eleanor Drummond
Eleanor Drummond, PhD Professor Senior Lecturer (Neuroscience) School of Medical Sciences; Bluesand Senior Research Fellow Brain & Mind Centre The University of Sydney, Australia About the Speaker: Eleanor Drummond is a neuroscientist who is passionate about understanding the cause of neurodegenerative disease. She received her PhD from the University of Western Australia in 2012. She then worked as postdoctoral fellow at Murdoch University (Australia) and New York University School of Medicine (USA), where she was appointed an Assistant Professor of Neurology in 2014. She returned back to Australia in 2018 to become a group leader at the Brain & Mind Centre at the University of Sydney after receiving the Bluesand Research Fellowship in Alzheimer's disease. Her team uses proteomics, neuropathology and cell culture approaches to identify the protein drivers of multiple neurodegenerative diseases including Alzheimer's disease, Frontotemporal Dementia, Epilepsy and Down syndrome. Her long-term goal is to determine the disease mechanisms that underlie these diseases and to use this information to identify new drug targets and biomarkers. She has developed new proteomics techniques that allows the localised analysis of proteins present in specific populations of cells or neuropathological lesions present in disease (e.g. amyloid plaques or neurofibrillary tangles) and that identify the protein interactors of key disease mediators such as tau and beta amyloid. She has generated the most comprehensive atlas available of all protein changes that occur throughout the progression of Alzheimer's in human brain tissue and has developed new cell culture approaches to determine the mechanistic role in disease for these new proteins identified in her proteomics studies. She is currently exploring the therapeutic potential of targeting these newly identified brain protein changes to treat Alzheimer's disease and is examining whether these protein changes are new potential blood biomarkers for Alzheimer's disease. Selected Recent Publications: 1. Walker JM, Orr ME, Orr TC, Thorn EL, Christie TD, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond E, White CL, Crary JF, Farrell K, Kautz TF, Daoud EV, Richardson TE (2024) Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy. Alzheimers Dement 20:783-797. 2. Leitner D, Kavanagh T, Kanshin E, Balcomb K, Pires G, Thierry M, Suazo JI, Schneider J, Ueberheide B, Drummond E, Wisniewski T (2024) Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment. Acta Neuropathol 148:9. 3. Askenazi M, Kavanagh T, Pires G, Ueberheide B, Wisniewski T, Drummond E (2023) Compilation of reported protein changes in the brain in Alzheimer's disease. Nat Commun 14:4466. 4. Kavanagh T, Halder A, Drummond E (2022) Tau interactome and RNA binding proteins in neurodegenerative diseases. Mol Neurodegener 17:66. 5. Leitner DF, Mills JD, Pires G, Faustin A, Drummond E, Kanshin E, Nayak S, Askenazi M, Verducci C, Chen BJ, Janitz M, Anink JJ, Baayen JC, Idema S, van Vliet EA, Devore S, Friedman D, Diehl B, Scott C, Thijs R et al. (2021) Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients. Neurology 96:e2639-e2652. |
