Shoi Shi

Shoi Shi

Principal Investigator

International Institute for Integrative Sleep Medicine (WPI-IIIS)

University of Tsukuba, Japan

About the Speaker:

Education/Academic background

2017 Ph.D. in Medicine (The University of Tokyo)

2017-2022 Assistant Professor, School of Medicine, The University of Tokyo

2020-2022 Project Researcher, School of Medicine, Keio University

2020-2022 ERATO UEDA Biological Timing Project Human Sleep Group GL

2022-present Visiting Researcher, School of Medicine, The University of Tokyo

2022-2025 Principal Investigator, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba

2025-Present Specially Appointed Assistant Professor, Principal Investigator, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba

Research Interest:

Sleep Disorders

Circadian Rhythms

Sleep, Memory and Learning

Selected Recent Publications:

1. Nishio M, Takeda N, Miyata R, Ito Y, Isayama T, Shi S, Wada Y (2025) Artificial Intelligence–Based Video Assessment of Neonatal State. JAMA Network Open 8:e2455948-e2455948.

2. Wang Y, Cao S, Tone D, Fujishima H, Yamada RG, Ohno R, Shi S, Matsuzawa K, Yada S, Kaneko M, Sakamoto H, Onishi T, Ukai-Tadenuma M, Ukai H, Hanashima C, Hirose K, Kiyonari H, Sumiyama K, Ode KL, Ueda HR (2024) Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles. Nature 636:412-421.

3. Sawada T, Iino Y, Yoshida K, Okazaki H, Nomura S, Shimizu C, Arima T, Juichi M, Zhou S, Kurabayashi N, Sakurai T, Yagishita S, Yanagisawa M, Toyoizumi T, Kasai H, Shi S (2024) Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics. Science 385:1459-1465.

4. Kon K, Ode KL, Mano T, Fujishima H, Takahashi RR, Tone D, Shimizu C, Shiono S, Yada S, Matsuzawa K, Yoshida SY, Garçon JY, Kaneko M, Shinohara Y, Yamada RG, Shi S, Miyamichi K, Sumiyama K, Kiyonari H, Susaki EA et al. (2024) Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation. Nat Commun 15:6054.

5. Katori M, Shi S, Ode KL, Tomita Y, Ueda HR (2022) The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes. Proc Natl Acad Sci U S A 119:e2116729119.