Fabio Di Domenico

Fabio Di Domenico, PhD

Full Professor

Department of Biochemical Sciences

Sapienza University of Rome, Italy

About the Speaker:

Fabio Di Domenico has extensive expertise in proteomics studies applied to neurodegenerative disease (e.g. AD, PD, DS and brain stroke) and lately is focusing his research on seeking the potential biomarker for Alzheimer’s disease.

Education

2009: Ph.D in Biochemistry at Sapienza University of Rome, Italy

2007-2008: Ph.D foreign student in the Laboratory of Neurochemistry at the University of Kentucky, Lexington, KY, U.S.A.

2005: Biological Sciences degree at Sapienza University of Rome, Italy

1998: Scientific High school degree

Work experience

2021 – present Full Professor position at the Department of Biochemical Sciences of Sapienza University of Rome

2015 – 2021 Associate Professor position at the Department of Biochemical Sciences of Sapienza University of Rome

2010 – 2015 Researcher (Assistant Professor) position at the Department of Biochemical Sciences of Sapienza University of Rome

2009 – 2010 Post-doctoral fellows (from Istituto Pasteur – Fondazione Cenci Bolognetti) at the Department of Chemistry of the University of Kentucky

2007 – 2008 PhD foreign student at the Department of Chemistry of the University of Kentucky

2005 – 2008 PhD student at the Department of Biochemical Sciences of Sapienza University of Rome

Honors and awards

2015: Junior faculty award at 12th International Conference on Alzheimer’s Disease and Parkinson’s Disease (APDP 2015)

2013: Associate editor of Journal of Alzheimer Disease – IOS press

2012: Selected among the best young “under 40” researchers of faculty of pharmacy and medicine of Sapienza University of Rome

Research Interest

Alzheimer disease, Down syndrome, proteomics, oxidative stress, neurodegeneration, protein homeostasis

Selected Recent Publications:

1. Lanzillotta C, Tramutola A, Lanzillotta S, Greco V, Pagnotta S, Sanchini C, Di Angelantonio S, Forte E, Rinaldo S, Paone A, Cutruzzolà F, Cimini FA, Barchetta I, Cavallo MG, Urbani A, Butterfield DA, Di Domenico F, Paul BD, Perluigi M, Duarte JMN et al. (2024) Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β. Redox Biol 73:103221.

2. Perluigi M, Di Domenico F, Butterfield DA (2024) Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease. Physiol Rev 104:103-197.

3. Perluigi M, Picca A, Montanari E, Calvani R, Marini F, Matassa R, Tramutola A, Villani A, Familiari G, Domenico FD, Butterfield DA, Oh KJ, Marzetti E, Valentini D, Barone E (2022) Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Alzheimers Dement 18:1498-1510.