Eugenio Barone

Eugenio Barone, PhD

Full Professor of Biochemistry

Faculty of Pharmacy and Medicine

Department of Biochemical Sciences “A. Rossi-Fanelli”

Sapienza University of Rome, Italy

About the Speaker:

Education

05/2006 Master Faculty of Pharmacy, University of Calabria

02/2011 PhD Institute of Pharmacology, Catholic University School of Medicine, Rome

12/2006 Licensure 01 Faculty of Pharmacy, University of Calabria (National Qualification as

Pharmacist)

2014 Licensure 02 Italian Ministry of Education, University and Research (MIUR) (National Scientific Qualification as Associate Professor of Biochemistry)

2017 Licensure 03 Italian Ministry of Education, University and Research (MIUR) (National Scientific Qualification

as Full Professor of Biochemistry)

Academic Appointments

2020-2022 Faculty of Medicine, Sapienza University of Rome. Faculty member for the Residency in Ophthalmology

10/2019-12/2023 Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome. Associate Professor of Biochemistry

2017-present Faculty of Medicine, Sapienza University of Rome. Faculty member for the Residency in Neurology

2017-present Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome. Faculty member for the PhD School in Biochemistry

10/2016-10/2019 Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome. Assistant Professor of Biochemistry

04/2015-12/2018 Faculty of Health Sciences, Universidad Autonoma de Chile, Chile. Associate Researcher

03/2016-09/2016 Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome. Post-doctoral Researcher

03/2014-02/2016 Department of Biochemical Sciences “A. Rossi-Fanelli”, Sapienza University of Rome. Post-doctoral Researcher under the People Programme of the European Union's Seventh Framework Programme

01/2012-01/2014 Brain Mind Institute, Swiss Federal Institute of Technology (EPFL). Post-doctoral Researcher

01/2010-01/2011 (a) Department of Molecular and Biomedical Pharmacology and (b) Department of Chemistry, Laboratory of Neurochemistry University of Kentucky. Visiting Researcher

The overarching goal of his laboratory is to clarify the link beteween defects of neurotrophic signaling (insulin and GLP1) and increased cell oxidative damage during ageing and neurodegeneration. Eugenio authored 71 publications, most of wich dealing with the role of oxidative stress in neurodegenerative disorders, i.e., Alzheimer disease and Down syndrome. He was recipient of prestigious grants from the Alzheimer Association, Jerome Lejaune Foundation, European Commission and Italian Ministry of Research, among the others. Eugenio was one of the firsts two repients of the SFRBM fellowship Awards and recipient of many international awards.

Selected Recent Publications:

1. Potier MC, Trisomy 21 Research Society executive board (2025) Advocating for increased awareness and research on Down syndrome. Lancet Neurol 24:288.

2. Lanzillotta C, Tramutola A, Lanzillotta S, Greco V, Pagnotta S, Sanchini C, Di Angelantonio S, Forte E, Rinaldo S, Paone A, Cutruzzolà F, Cimini FA, Barchetta I, Cavallo MG, Urbani A, Butterfield DA, Di Domenico F, Paul BD, Perluigi M, Duarte JMN et al. (2024) Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β. Redox Biol 73:103221.

3. Ripoli C, Dagliyan O, Renna P, Pastore F, Paciello F, Sollazzo R, Rinaudo M, Battistoni M, Martini S, Tramutola A, Sattin A, Barone E, Saneyoshi T, Fellin T, Hayashi Y, Grassi C (2023) Engineering memory with an extrinsically disordered kinase. Sci Adv 9:eadh1110.

4. Perluigi M, Barone E (2022) Aberrant protein networks in Alzheimer disease. Nat Rev Neurol 18:18:255-256.

5. Perluigi M, Picca A, Montanari E, Calvani R, Marini F, Matassa R, Tramutola A, Villani A, Familiari G, Domenico FD, Butterfield DA, Oh KJ, Marzetti E, Valentini D, Barone E (2022) Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Alzheimers Dement 18:1498-1510.