Thomas K Karikari

Thomas K Karikari, PhD

助理教授

精神病学系

匹兹堡大学医学院，美国

关于演讲人：

教育培训经历：

华威大学神经科学博士

哥德堡大学神经科学博士后

专业领域兼职：

国际神经化学学会，神经化学教育援助委员会

荣誉与奖项：

瑞典阿尔茨海默病基金会，最佳阿尔茨海默病出版物奖

北欧临床化学联合会，Astrup奖

研究方向

阿尔茨海默病脑病理改变，阿尔茨海默病诊断的血液生物标志物

近年发表文章：

1. Islam T, Hill E, Abrahamson EE, Servaes S, Smirnov DS, Zeng X, Sehrawat A, Chen Y, Kac PR, Kvartsberg H, Olsson M, Sjons E, Gonzalez-Ortiz F, Therriault J, Tissot C, Del Popolo I, Rahmouni N, Richardson A, Mitchell V, Zetterberg H, Pascoal TA et al. (2025) Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease. Nat Med. 2025 Feb 10. Online ahead of print.

2. Therriault J, Schindler SE, Salvadó G, Pascoal TA, Benedet AL, Ashton NJ, Karikari TK, Apostolova L, Murray ME, Verberk I, Vogel JW, La Joie R, Gauthier S, Teunissen C, Rabinovici GD, Zetterberg H, Bateman RJ, Scheltens P, Blennow K, Sperling R et al. (2024) Biomarker-based staging of Alzheimer disease: rationale and clinical applications. Nat Rev Neurol 20:232-244.

3. Balusu S, Horré K, Thrupp N, Craessaerts K, Snellinx A, Serneels L, T'Syen D, Chrysidou I, Arranz AM, Sierksma A, Simrén J, Karikari TK, Zetterberg H, Chen WT, Thal DR, Salta E, Fiers M, De Strooper B (2023) MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease. Science 381:1176-1182.

4. Milà-Alomà M, Ashton NJ, Shekari M, Salvadó G, Ortiz-Romero P, Montoliu-Gaya L, Benedet AL, Karikari TK, Lantero-Rodriguez J, Vanmechelen E, Day TA, González-Escalante A, Sánchez-Benavides G, Minguillon C, Fauria K, Molinuevo JL, Dage JL, Zetterberg H, Gispert JD, Suárez-Calvet M et al. (2022) Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease. Nat Med 28:1797-1801.

5. Ashton NJ, Janelidze S, Mattsson-Carlgren N, Binette AP, Strandberg O, Brum WS, Karikari TK, González-Ortiz F, Di Molfetta G, Meda FJ, Jonaitis EM, Koscik RL, Cody K, Betthauser TJ, Li Y, Vanmechelen E, Palmqvist S, Stomrud E, Bateman RJ, Zetterberg H et al. (2022) Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease monitoring. Nat Med 28:2555-2562.